Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

Metazoans viability depends on their ability to regulate metabolic processes and also to respond to harmful challenges by mounting anti‐stress responses; these adaptations were fundamental forces during evolution. Central to anti‐stress responses are a number of short‐lived transcription factors tha...

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Bibliografski detalji
Izdano u:Aging Cell
Glavni autori: Tsakiri, Eleni N., Gumeni, Sentiljana, Iliaki, Kalliopi K., Benaki, Dimitra, Vougas, Konstantinos, Sykiotis, Gerasimos P., Gorgoulis, Vassilis G., Mikros, Emmanuel, Scorrano, Luca, Trougakos, Ioannis P.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Original Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351879/
https://ncbi.nlm.nih.gov/pubmed/30537423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12845
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