Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

Metazoans viability depends on their ability to regulate metabolic processes and also to respond to harmful challenges by mounting anti‐stress responses; these adaptations were fundamental forces during evolution. Central to anti‐stress responses are a number of short‐lived transcription factors tha...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Tsakiri, Eleni N., Gumeni, Sentiljana, Iliaki, Kalliopi K., Benaki, Dimitra, Vougas, Konstantinos, Sykiotis, Gerasimos P., Gorgoulis, Vassilis G., Mikros, Emmanuel, Scorrano, Luca, Trougakos, Ioannis P.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
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Original Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351879/
https://ncbi.nlm.nih.gov/pubmed/30537423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12845
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