Lymph nodes as barriers to T‐cell rejuvenation in aging mice and nonhuman primates

In youth, thymic involution curtails production of new naïve T cells, placing the onus of T‐cell maintenance upon secondary lymphoid organs (SLO). This peripheral maintenance preserves the size of the T‐cell pool for much of the lifespan, but wanes in the last third of life, leading to a dearth of n...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Thompson, Heather L., Smithey, Megan J., Uhrlaub, Jennifer L., Jeftić, Ilija, Jergović, Mladen, White, Sarah E., Currier, Noreen, Lang, Anna M., Okoye, Afam, Park, Byung, Picker, Louis J., Surh, Charles D., Nikolich‐Žugich, Janko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351843/
https://ncbi.nlm.nih.gov/pubmed/30430748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12865
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