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Identification and Verification of Ubiquitin-Activated Bacterial Phospholipases

ExoU is a potent type III secretion system effector that is injected directly into mammalian cells by the opportunistic pathogen Pseudomonas aeruginosa. As a ubiquitin-activated phospholipase A(2) (PLA(2)), ExoU exhibits cytotoxicity by cleaving membrane phospholipids, resulting in lysis of the host...

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Bibliografiske detaljer
Udgivet i:J Bacteriol
Main Authors: Tessmer, Maxx H., Anderson, David M., Pickrum, Adam M., Riegert, Molly O., Frank, Dara W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351748/
https://ncbi.nlm.nih.gov/pubmed/30455285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00623-18
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