Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish

Patients with an inherited inability to synthesize sufficient amounts of cholesterol develop congenital malformations of the skull, toes, kidney and heart. As development of these structures depends on functional cilia we investigated whether cholesterol regulates ciliogenesis through inhibition of...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Maerz, Lars D., Burkhalter, Martin D., Schilpp, Carolin, Wittekindt, Oliver H., Frick, Manfred, Philipp, Melanie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351647/
https://ncbi.nlm.nih.gov/pubmed/30729178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0272-7
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