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New insights into the coordination between the polymerization and 3′-5′ exonuclease activities in ϕ29 DNA polymerase

Bacteriophage ϕ29 DNA polymerase has two activities: DNA polymerization and 3′-5′ exonucleolysis governed by catalytic sites present in two structurally distant domains. These domains must work together to allow the correct replication of the template and to prevent the accumulation of errors in the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: del Prado, Alicia, Rodríguez, Irene, Lázaro, José María, Moreno-Morcillo, María, de Vega, Miguel, Salas, Margarita
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351526/
https://ncbi.nlm.nih.gov/pubmed/30696917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37513-7
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