LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats

White matter injury (WMI) is associated with motor deficits and cognitive dysfunctions in subarachnoid hemorrhage (SAH) patients. Therapeutic strategy targeting WMI would likely improve the neurological outcomes after SAH. Low-density lipoprotein receptor-related protein-1 (LRP1), a scavenger recept...

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Publicat a:Redox Biol
Autors principals: Peng, Jianhua, Pang, Jinwei, Huang, Lei, Enkhjargal, Budbazar, Zhang, Tongyu, Mo, Jun, Wu, Pei, Xu, Weilin, Zuo, Yuchun, Peng, Jun, Zuo, Gang, Chen, Ligang, Tang, Jiping, Zhang, John H., Jiang, Yong
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351270/
https://ncbi.nlm.nih.gov/pubmed/30703614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101121
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