A non-canonical autophagy-dependent role of the ATG16L1(T300A) variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence

50% of Caucasians carry a Thr300Ala variant (T300A) in the protein encoded by the macroautophagy/autophagy gene ATG16L1. Here, we show that the T300A variant confers protection against urinary tract infections (UTIs), the most common infectious disease in women. Using knockin mice carrying the human...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Wang, Caihong, Bauckman, Kyle A., Ross, Adam S. B., Symington, Jane W., Ligon, Marianne M., Scholtes, Gael, Kumar, Akhil, Chang, Hao-Wei, Twentyman, Joy, Fashemi, Bisiayo E., Xavier, Ramnik J., Mysorekar, Indira U.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper - Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351132/
https://ncbi.nlm.nih.gov/pubmed/30335568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1535290
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