ATG16L1 deficiency in macrophages drives clearance of Uropathogenic E. coli in an IL-1β dependent manner

Urinary Tract Infections (UTIs) are frequent, commonly recurrent, and costly. Deficiency in a key autophagy protein, ATG16L1, protects mice from infection with the predominant bacterial cause of UTIs, Uropathogenic E. coli (UPEC). Here, we report that loss of ATG16L1 in macrophages accounts for this...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Symington, Jane W., Wang, Caihong, Twentyman, Joy, Boaitey, Nana Owusu, Schwendener, Reto, Núñez, Gabriel, Schilling, Joel D., Mysorekar, Indira U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532666/
https://ncbi.nlm.nih.gov/pubmed/25669147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2015.7
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