Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Fanconi anemia (FA) is characterized by developmental abnormalities, bone marrow failure, and cancer predisposition. FA cells are hypersensitive to DNA replicative stress and accumulate co-transcriptional R-loops. Here, we use the Damage At RNA Transcription assay to reveal colocalization of FANCD2...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Liang, Zhuobin, Liang, Fengshan, Teng, Yaqun, Chen, Xiaoyong, Liu, Jingchun, Longerich, Simonne, Rao, Timsi, Green, Allison M., Collins, Natalie B., Xiong, Yong, Lan, Li, Sung, Patrick, Kupfer, Gary M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350941/
https://ncbi.nlm.nih.gov/pubmed/30650351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.084
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