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FANCI Binds Branched DNA and Is Monoubiquitinated by UBE2T-FANCL

FANCI is integral to the Fanconi anemia (FA) pathway of DNA damage repair. Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 and relocalizes to chromatin, where it functions with monoubiquitinated FANCD2 to facilitate DNA repair. We show that FANCI and its C-terminal frag...

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Detalhes bibliográficos
Main Authors: Longerich, Simonne, San Filippo, Joseph, Liu, Dongqing, Sung, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749091/
https://ncbi.nlm.nih.gov/pubmed/19589784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.038075
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