ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

The A20-binding inhibitor of NF-κB 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component of the tumor progression locus 2 (Tpl2) kinase complex. We generated a knock-in mouse expressing the ubiquitin-binding–defective mutant ABIN2[D310N]. The expression of Tpl2 and its a...

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Vydáno v:J Immunol
Hlavní autoři: Nanda, Sambit K., Nagamori, Tsunehisa, Windheim, Mark, Amu, Sylvia, Aviello, Gabriella, Patterson-Kane, Janet, Arthur, J. Simon C., Ley, Steven C., Fallon, Padraic, Cohen, Philip
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350896/
https://ncbi.nlm.nih.gov/pubmed/30355787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700614
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