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Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

Most neurodegenerative diseases are characterized by the accumulation of protein aggregates, some of which are toxic to cells. Mounting evidence demonstrates that in several diseases, protein aggregates can pass from neuron to neuron along connected networks, although the role of this spreading phen...

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Pubblicato in:Annu Rev Cell Dev Biol
Autori principali: Davis, Albert A., Leyns, Cheryl E.G., Holtzman, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350082/
https://ncbi.nlm.nih.gov/pubmed/30044648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-cellbio-100617-062636
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