Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native Nanodiscs

Recent studies have shown that the small GTPase KRAS adopts multiple orientations with respect to the plane of anionic model membranes, whereby either the three C-terminal helices or the three N-terminal β-strands of the catalytic domain face the membrane. This has functional implications because, i...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Prakash, Priyanka, Litwin, Douglas, Liang, Hong, Sarkar-Banerjee, Suparna, Dolino, Drew, Zhou, Yong, Hancock, John F., Jayaraman, Vasanthi, Gorfe, Alemayehu A.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2019
Assuntos:
Biophysical Letter
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350008/
https://ncbi.nlm.nih.gov/pubmed/30616834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.12.011
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