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Morphine Exacerbates Post-Fracture Nociceptive Sensitization, Functional Impairment, and Microglial Activation in Mice
BACKGROUND: Emerging evidence suggests that opioid use immediately following surgery and trauma may worsen outcomes. In these studies, we sought to determine if morphine administered for a clinically relevant time period (7 days) in a tibia fracture orthopedic surgery model had adverse effects on po...
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| Publicado no: | Anesthesiology |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6349476/ https://ncbi.nlm.nih.gov/pubmed/30418215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002495 |
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