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Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice

CRISPR/Cas9 is a powerful technology widely used for genome editing, with the potential to be used for correcting a wide variety of deleterious disease-causing mutations. However, the technique tends to generate more indels (insertions and deletions) than precise modifications at the target sites, w...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Miao, Kai, Zhang, Xin, Su, Sek Man, Zeng, Jianming, Huang, Zebin, Chan, Un In, Xu, Xiaoling, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349110/
https://ncbi.nlm.nih.gov/pubmed/30487289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006496
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