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NP220 mediates silencing of unintegrated retroviral DNA

The entry of foreign DNA into many mammalian cell types triggers the innate immune system, a complex set of responses directed at preventing infection by pathogens. One aspect of the response is the potent epigenetic silencing of incoming viral DNAs(1), including the extrachromosomal DNAs formed imm...

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Bibliographic Details
Published in:Nature
Main Authors: Zhu, Yiping, Wang, Gary Z., Cingöz, Oya, Goff, Stephen P.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349045/
https://ncbi.nlm.nih.gov/pubmed/30487602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0750-6
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