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The E3 ligases Itch and WWP2 cooperate to limit T(H)2 differentiation by enhancing signaling through the TCR
The mechanisms by which the sensitivity of naive CD4(+) T cells to stimulation by the cognate antigen via the T cell antigen receptor (TCR) determines their differentiation into distinct helper T cell subsets remain elusive. Here we demonstrate functional collaboration of the ubiquitin E3 ligases It...
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| Publicado en: | Nat Immunol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6348860/ https://ncbi.nlm.nih.gov/pubmed/29925997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0137-8 |
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