Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

[Image: see text] Developing PROTACs to redirect the ubiquitination activity of E3 ligases and potently degrade a target protein within cells can be a lengthy and unpredictable process, and it remains unclear whether any combination of E3 and target might be productive for degradation. We describe a...

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Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Zoppi, Vittoria, Hughes, Scott J., Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M., Daniels, Danette L., Spallarossa, Andrea, Ciulli, Alessio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2018
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348446/
https://ncbi.nlm.nih.gov/pubmed/30540463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01413
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