CD39 MEDIATED REGULATION OF TH17-CELL EFFECTOR FUNCTION IS IMPAIRED IN JUVENILE AUTOIMMUNE LIVER DISEASE

BACKGROUND & AIMS: T-helper-type 17 (Th17) cells are involved in autoimmune tissue damage. CD39 is an ectonucleotidase that catalyzes extracellular ATP/ADP hydrolysis, culminating in the generation of immunosuppressive adenosine. Functional CD39 expression confers immunosuppressive properties up...

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Détails bibliographiques
Publié dans:J Autoimmun
Auteurs principaux: Liberal, Rodrigo, Grant, Charlotte R, Ma, Yun, Csizmadia, Eva, Jiang, Zhenghui Gordon, Heneghan, Michael A, Yee, Eric U, Mieli-Vergani, Giorgina, Vergani, Diego, Robson, Simon C, Longhi, Maria Serena
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348153/
https://ncbi.nlm.nih.gov/pubmed/27210814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2016.05.005
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