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Exposure of solvent inaccessible regions in the amyloidogenic protein human SOD1 determined by hydroxyl radical footprinting
Solvent-accessibility change plays a critical role in protein misfolding and aggregation, the culprit for several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Mass spectrometry-based hydroxyl radical (∙OH) protein footprinting has evolved as a powerful and fast tool in...
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| Veröffentlicht in: | J Am Soc Mass Spectrom |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6347482/ https://ncbi.nlm.nih.gov/pubmed/30328005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-018-2075-y |
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