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FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons

Mutations in the nuclear localization signal of the RNA binding protein FUS cause both Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). These mutations result in a loss of FUS from the nucleus and the formation of FUS-containing cytoplasmic aggregates in patients. To better und...

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Publicat a:Brain Res
Autors principals: Machamer, James B., Woolums, Brian M., Fuller, Gregory, Lloyd, Thomas E.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347466/
https://ncbi.nlm.nih.gov/pubmed/29625118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2018.03.037
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