Cell-Free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers Within Hydrogels

Eukaryotic cells contain assemblies of RNAs and proteins termed RNA granules. Many proteins within these bodies contain KH or RRM RNA binding domains as well as low complexity (LC) sequences of unknown function. Exposure of cell or tissue lysates to a biotinylated isoxazole (b-isox) chemical precipi...

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Publicat a:Cell
Autors principals: Kato, Masato, Han, Tina, Xie, Shanhai, Shi, Kevin, Du, Xinlin, Wu, Leeju, Mirzaei, Hamid, Goldsmith, Elizabeth, Longgood, Jamie, Pei, Jimin, Grishin, Nick, Frantz, Doug, Schneider, Jay, Chen, She, Li, Lin, Sawaya, Michael, Eisenberg, David, Tycko, Robert, McKnight, Steven L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347373/
https://ncbi.nlm.nih.gov/pubmed/22579281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.04.017
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