Synthetic lethality guiding selection of drug combinations in ovarian cancer

BACKGROUND: Synthetic lethality describes a relationship between two genes where single loss of either gene does not trigger significant impact on cell viability, but simultaneous loss of both gene functions results in lethality. Targeting synthetic lethal interactions with drug combinations promise...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Heinzel, Andreas, Marhold, Maximilian, Mayer, Paul, Schwarz, Michael, Tomasich, Erwin, Lukas, Arno, Krainer, Michael, Perco, Paul
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347359/
https://ncbi.nlm.nih.gov/pubmed/30682083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210859
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