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Synthetic lethality guiding selection of drug combinations in ovarian cancer

BACKGROUND: Synthetic lethality describes a relationship between two genes where single loss of either gene does not trigger significant impact on cell viability, but simultaneous loss of both gene functions results in lethality. Targeting synthetic lethal interactions with drug combinations promise...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Heinzel, Andreas, Marhold, Maximilian, Mayer, Paul, Schwarz, Michael, Tomasich, Erwin, Lukas, Arno, Krainer, Michael, Perco, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347359/
https://ncbi.nlm.nih.gov/pubmed/30682083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210859
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