Interaction of two antitumor peptides with membrane lipids – Influence of phosphatidylserine and cholesterol on specificity for melanoma cells

R-DIM-P-LF11-322 and DIM-LF11-318, derived from the cationic human host defense peptide lactoferricin show antitumor activity against human melanoma. While R-DIM-P-LF11-322 interacts specifically with cancer cells, the non-specific DIM-LF11-318 exhibits as well activity against non-neoplastic cells....

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Udgivet i:PLoS One
Main Authors: Wodlej, Christina, Riedl, Sabrina, Rinner, Beate, Leber, Regina, Drechsler, Carina, Voelker, Dennis R., Choi, Jae-Yeon, Lohner, Karl, Zweytick, Dagmar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347193/
https://ncbi.nlm.nih.gov/pubmed/30682171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211187
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