Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity

Abdominal pain represents a significant complaint in patients with irritable bowel syndrome (IBS). While the etiology of IBS is incompletely understood, prior exposure to gastrointestinal inflammation or psychologic stress is frequently associated with the development of symptoms. Inflammation or st...

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Udgivet i:J Pharmacol Exp Ther
Main Authors: Russell, John P., Mohammadi, Ehsan, Ligon, Casey O., Johnson, Anthony C., Gershon, Michael D., Rao, Meenakshi, Shen, Yuhong, Chan, Chi-Chung, Eidam, Hilary S., DeMartino, Michael P., Cheung, Mui, Oliff, Allen I., Kumar, Sanjay, Greenwood-Van Meerveld, Beverley
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2019
Fag:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346376/
https://ncbi.nlm.nih.gov/pubmed/30413627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.252973
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