Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-Sensitization

Bladder pain syndrome (BPS) is poorly understood; however, there is a female predominance and comorbidity with irritable bowel syndrome (IBS). Here we test the hypothesis that linaclotide, a guanylate cyclase-C (GC-C) agonist approved for the treatment of IBS with constipation (IBS-C), may represent...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Mohammadi, Ehsan N., Ligon, Casey O., Silos-Santiago, Ada, Ge, Pei, Kurtz, Caroline, Higgins, Carolyn, Hannig, Gerhard, Greenwood-Van Meerveld, Beverley
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2018
Soggetti:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034264/
https://ncbi.nlm.nih.gov/pubmed/29784661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.248567
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