Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

[Image: see text] Abdominal pain and abnormal bowel habits represent major symptoms for irritable bowel syndrome (IBS) patients that are not adequately managed. Although the etiology of IBS is not completely understood, many of the functions of the gastrointestinal (GI) tract are regulated by the en...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Schenck Eidam, Hilary, Russell, John, Raha, Kaushik, DeMartino, Michael, Qin, Donghui, Guan, Huiping Amy, Zhang, Zhiliu, Zhen, Gong, Yu, Haiyu, Wu, Chengde, Pan, Yan, Joberty, Gerard, Zinn, Nico, Laquerre, Sylvie, Robinson, Sharon, White, Angela, Giddings, Amanda, Mohammadi, Ehsan, Greenwood-Van Meerveld, Beverly, Oliff, Allen, Kumar, Sanjay, Cheung, Mui
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047170/
https://ncbi.nlm.nih.gov/pubmed/30034590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00035
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