IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy. Here, we report that an IRE1α RNase-specific inhibitor, MKC8866,...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Sheng, Xia, Nenseth, Hatice Zeynep, Qu, Su, Kuzu, Omer F., Frahnow, Turid, Simon, Lukas, Greene, Stephanie, Zeng, Qingping, Fazli, Ladan, Rennie, Paul S., Mills, Ian G., Danielsen, Håvard, Theis, Fabian, Patterson, John B., Jin, Yang, Saatcioglu, Fahri
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345973/
https://ncbi.nlm.nih.gov/pubmed/30679434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08152-3
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker