Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L

Pulmonary fibrosis is a progressive disease characterized by a widespread accumulation of myofibroblasts and extracellular matrix components. Growing evidences support that cysteine cathepsins, embracing cathepsin B (CatB) that affects TGF-β1-driven Smad pathway, along with their extracellular inhib...

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Publicado no:Sci Rep
Main Authors: Saidi, Ahlame, Kasabova, Mariana, Vanderlynden, Lise, Wartenberg, Mylène, Kara-Ali, Ghania Hounana, Marc, Daniel, Lecaille, Fabien, Lalmanach, Gilles
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345753/
https://ncbi.nlm.nih.gov/pubmed/30679571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36858-3
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