Cysteine Cathepsins S and L Modulate Anti-angiogenic Activities of Human Endostatin

Human endostatin, a potent anti-angiogenic protein, is generated by release of the C terminus of collagen XVIII. Here, we propose that cysteine cathepsins are involved in both the liberation and activation of bioactive endostatin fragments, thus regulating their anti-angiogenic properties. Cathepsin...

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Detalhes bibliográficos
Main Authors: Veillard, Florian, Saidi, Ahlame, Burden, Roberta E., Scott, Christopher J., Gillet, Ludovic, Lecaille, Fabien, Lalmanach, Gilles
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199463/
https://ncbi.nlm.nih.gov/pubmed/21896479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284869
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