mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumors

BACKGROUND: Full-length tissue factor (flTF) and alternatively spliced TF (asTF) contribute to growth and spread of pancreatic ductal adenocarcinoma. It is unknown, however, if flTF and/or asTF contribute to pathobiology of pancreatic neuroendocrine tumors (pNET). OBJECTIVE: To assess TF expression...

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Veröffentlicht in:J Thromb Haemost
Hauptverfasser: Lewis, Clayton S, Thomas, Hala Elnakat, Orr-Asman, Melissa, Green, Lisa C, Boody, Rachel E, Matiash, Kateryna, Karve, Aniruddha, Hisada, Yohei M., Davis, Harold W, Qi, Xiaoyang, Mercer, Carol, Lucas, Fred V, Aronow, Bruce J., Mackman, Nigel, Versteeg, Henri H, Bogdanov, Vladimir Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345540/
https://ncbi.nlm.nih.gov/pubmed/30472780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14342
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