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Molecular mechanism of point mutation-induced Monopolar spindle 1 (Mps1/TTK) inhibitor resistance revealed by a comprehensive molecular modeling study

BACKGROUND: Monopolar spindle 1 (Mps1/TTK) is an apical dual-specificity protein kinase in the spindle assembly checkpoint (SAC) that guarantees accurate segregation of chromosomes during mitosis. High levels of Mps1 are found in various types of human malignancies, such as glioblastoma, osteosarcom...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Han, Yan, Wu, Yungang, Xu, Yi, Guo, Wentao, Zhang, Na, Wang, Xiaoyi
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345219/
https://ncbi.nlm.nih.gov/pubmed/30693152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.6299
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