Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer

Loss of cell-cycle control is a hallmark of human cancer. Cell-cycle checkpoints are essential for maintaining genome integrity and balanced growth and division. They are specifically deregulated in cancer cells and contain regulators that represent potential therapeutic targets. Monopolar spindle 1...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mason, Jacqueline M., Wei, Xin, Fletcher, Graham C., Kiarash, Reza, Brokx, Richard, Hodgson, Richard, Beletskaya, Irina, Bray, Mark R., Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373378/
https://ncbi.nlm.nih.gov/pubmed/28270606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700234114
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