Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA)

Extending from a study we recently published examining the anti-trypanosomal effects of a series of GroEL/ES inhibitors based on a pseudo-symmetrical bis-sulfonamido-2-phenylbenzoxazole scaffold, here, we report the antibiotic effects of asymmetric analogs of this scaffold against a panel of bacteri...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Abdeen, Sanofar, Kunkle, Trent, Salim, Nilshad, Ray, Anne-Marie, Mammadova, Najiba, Summers, Corey, Stevens, Mckayla, Ambrose, Andrew J., Park, Yangshin, Schultz, Peter G., Horwich, Arthur L., Hoang, Quyen, Chapman, Eli, Johnson, Steven M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345161/
https://ncbi.nlm.nih.gov/pubmed/30060666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00989
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