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Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons

The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences o...

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Bibliografiske detaljer
Udgivet i:Euro Surveill
Main Authors: Gubareva, Larisa V, Mishin, Vasiliy P, Patel, Mira C, Chesnokov, Anton, Nguyen, Ha T, De La Cruz, Juan, Spencer, Sarah, Campbell, Angela P, Sinner, Mallory, Reid, Heather, Garten, Rebecca, Katz, Jackie M, Fry, Alicia M, Barnes, John, Wentworth, David E
Format: Artigo
Sprog:Inglês
Udgivet: European Centre for Disease Prevention and Control (ECDC) 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344838/
https://ncbi.nlm.nih.gov/pubmed/30670144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1800666
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