Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons

The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences o...

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Enregistré dans:
Détails bibliographiques
Publié dans:Euro Surveill
Auteurs principaux: Gubareva, Larisa V, Mishin, Vasiliy P, Patel, Mira C, Chesnokov, Anton, Nguyen, Ha T, De La Cruz, Juan, Spencer, Sarah, Campbell, Angela P, Sinner, Mallory, Reid, Heather, Garten, Rebecca, Katz, Jackie M, Fry, Alicia M, Barnes, John, Wentworth, David E
Format: Artigo
Langue:Inglês
Publié: European Centre for Disease Prevention and Control (ECDC) 2019
Sujets:
Rapid Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344838/
https://ncbi.nlm.nih.gov/pubmed/30670144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1800666
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