Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods

Baloxavir, a new antiviral drug targeting cap-dependent endonuclease activity of polymerase acidic (PA) protein of influenza viruses, is now approved in multiple countries. Several substitutions at isoleucine 38 in PA protein (e.g., PA-I38T) have been associated with decreased baloxavir susceptibili...

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Bibliografiske detaljer
Udgivet i:Antiviral Res
Main Authors: Patel, Mira C., Mishin, Vasiliy P., De La Cruz, Juan A., Chesnokov, Anton, Nguyen, Ha T., Wilson, Malania M., Barnes, John, Kondor, Rebecca J.G., Wentworth, David E., Gubareva, Larisa V.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426223/
https://ncbi.nlm.nih.gov/pubmed/32798601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2020.104906
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