Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability

Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells. Here, we identify a previously unknown role for cohesin. We find that cohesin is required to repress...

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Publié dans:Mol Cell
Auteurs principaux: Meisenberg, Cornelia, Pinder, Sarah I., Hopkins, Suzanna R., Wooller, Sarah K., Benstead-Hume, Graeme, Pearl, Frances M.G., Jeggo, Penny A., Downs, Jessica A.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344341/
https://ncbi.nlm.nih.gov/pubmed/30554942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.11.001
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