Mito-Tempo Protects against Acute Liver Injury but Induces Limited Secondary Apoptosis during the Late Phase of Acetaminophen Hepatotoxicity

We previously reported that delayed treatment with Mito-tempo (MT), a mitochondrial targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. However, whether this protection is sustained to the late phase of...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Du, Kuo, Ramachandran, Anup, Weemhoff, James L., Woolbright, Benjamin L., Jaeschke, Andrew H., Chao, Xiaojuan, Ding, Wen-Xing, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344320/
https://ncbi.nlm.nih.gov/pubmed/30324313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2331-8
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