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Design Criteria For Minimalist Mimics Of Protein-protein Interface Segments

Small molecules that can interrupt or inhibit protein-protein interactions (PPIs) are valuable as probes in chemical biology and medicinal chemistry, but they are also notoriously difficult to develop. Design of non-peptidic small molecules that mimic amino acid side-chain interactions in PPIs (“min...

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Vydáno v:Org Biomol Chem
Hlavní autoři: Taechalertpaisarn, Jaru, Lyu, Rui-Liang, Arancillo, Maritess, Lin, Chen-Ming, Jiang, Zhengyang, Perez, Lisa M., Ioerger, Thomas R., Burgess, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344279/
https://ncbi.nlm.nih.gov/pubmed/30629068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02901f
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