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Antigen binding allosterically promotes Fc receptor recognition

A key question in immunology is whether antigen recognition and Fc receptor (FcR) binding are allosterically linked. This question is also relevant for therapeutic antibody design. Antibody Fab and Fc domains are connected by flexible unstructured hinge region. Fc chains have conserved glycosylation...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:MAbs
मुख्य लेखकों: Zhao, Jun, Nussinov, Ruth, Ma, Buyong
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Taylor & Francis 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343797/
https://ncbi.nlm.nih.gov/pubmed/30212263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1522178
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