Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins

Histone deacetylase (HDAC) inhibitors may have therapeutic utility in multiple neurological and psychiatric disorders, but the underlying mechanisms remain unclear. Here, we identify BRD4, a BET bromodomain reader of acetyl-lysine histones, as an essential component involved in potentiated expressio...

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Publicado en:J Neurosci
Main Authors: Sartor, Gregory C., Malvezzi, Andrea M., Kumar, Ashok, Andrade, Nadja S., Wiedner, Hannah J., Vilca, Samara J., Janczura, Karolina J., Bagheri, Amir, Al-Ali, Hassan, Powell, Samuel K., Brown, Peyton T., Volmar, Claude H., Foster, Thomas C., Zeier, Zane, Wahlestedt, Claes
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343644/
https://ncbi.nlm.nih.gov/pubmed/30504275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1604-18.2018
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