Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins

Histone deacetylase (HDAC) inhibitors may have therapeutic utility in multiple neurological and psychiatric disorders, but the underlying mechanisms remain unclear. Here, we identify BRD4, a BET bromodomain reader of acetyl-lysine histones, as an essential component involved in potentiated expressio...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Sartor, Gregory C., Malvezzi, Andrea M., Kumar, Ashok, Andrade, Nadja S., Wiedner, Hannah J., Vilca, Samara J., Janczura, Karolina J., Bagheri, Amir, Al-Ali, Hassan, Powell, Samuel K., Brown, Peyton T., Volmar, Claude H., Foster, Thomas C., Zeier, Zane, Wahlestedt, Claes
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2019
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343644/
https://ncbi.nlm.nih.gov/pubmed/30504275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1604-18.2018
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