Effect of Cilostazol on the Pharmacokinetics of Simvastatin in Healthy Subjects

PURPOSE: We evaluated potential drug-drug interactions between cilostazol and simvastatin, both CYP3A substrates, in healthy subjects. METHODS: An open-label, two-period, fixed-sequence clinical study was conducted. Seventeen subjects were given a single oral dose of simvastatin 40 mg on day 1 and m...

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Vydáno v:Biomed Res Int
Hlavní autoři: Kim, Jung-Ryul, Jung, Jin Ah, Kim, Seokuee, Huh, Wooseong, Ghim, Jong-Lyul, Shin, Jae-Gook, Ko, Jae-Wook
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343132/
https://ncbi.nlm.nih.gov/pubmed/30729119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1365180
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