Targeted Elimination of Tumorigenic Human Pluripotent Stem Cells Using Suicide-inducing Virus-like Particles

Sensitization to prodrugs via transgenic expression of suicide genes is a leading strategy for the selective elimination of potentially tumorigenic human pluripotent stem cells (hPSCs) in regenerative medicine, but transgenic modification poses safety risks such as deleterious mutagenesis. We descri...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Rampoldi, Antonio, Crooke, Stephen N., Preininger, Marcela K., Jha, Rajneesh, Maxwell, Joshua, Ding, Lingmei, Spearman, Paul, Finn, M.G., Xu, Chunhui
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343126/
https://ncbi.nlm.nih.gov/pubmed/29979576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00490
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