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Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

Tumorigenesis requires accumulation of genetic and epigenetic alterations, some of which drive tumor initiation. “Oncogene addiction” describes the phenomenon that (1) well-established cancers are dependent on one mutated oncogene or pathway for the maintenance of a malignant phenotype and that (2)...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Yee, Christopher H., Zheng, Zongyu, Shuman, Lauren, Yamashita, Hironobu, Warrick, Joshua I., Wu, Xue-Ru, Raman, Jay D., DeGraff, David J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342925/
https://ncbi.nlm.nih.gov/pubmed/30670749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36720-6
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