Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet

We have previously shown that high fat diet (HFD) for 2 weeks increases airway hyperresponsiveness (AHR) to methacholine challenge in C57BL/6J mice in association with an increase in IL-1β levels in lung tissue. We hypothesize that obesity increases AHR via the IL-1β mechanism, which can be prevente...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Younas, Haris, Vieira, Marcela, Gu, Chenjuan, Lee, Rachel, Shin, Mi-kyung, Berger, Slava, Loube, Jeff, Nelson, Andrew, Bevans-Fonti, Shannon, Zhong, Qiong, D’Alessio, Franco R., McCormack, Meredith C., Hansel, Nadia N, Mitzner, Wayne, Polotsky, Vsevolod Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342916/
https://ncbi.nlm.nih.gov/pubmed/30670753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36651-2
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