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PHARMACOKINETICS AND PHARMACODYNAMICS OF ESCALATING DOSES OF SHetA2 AFTER VAGINAL ADMINISTRATION TO MICE
SHetA2 is a novel compound with strong potential to treat cervical dysplasia, but its low aqueous solubility limits its oral bioavailability. A vaginal suppository achieved SHetA2 cervix concentrations that were several fold above the predicted therapeutic levels. Thus, we aimed to determine the min...
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| Udgivet i: | J Pharm Sci |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6342475/ https://ncbi.nlm.nih.gov/pubmed/30196041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.08.024 |
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