PHARMACOKINETICS AND PHARMACODYNAMICS OF ESCALATING DOSES OF SHetA2 AFTER VAGINAL ADMINISTRATION TO MICE

SHetA2 is a novel compound with strong potential to treat cervical dysplasia, but its low aqueous solubility limits its oral bioavailability. A vaginal suppository achieved SHetA2 cervix concentrations that were several fold above the predicted therapeutic levels. Thus, we aimed to determine the min...

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Vydáno v:J Pharm Sci
Hlavní autoři: Mahjabeen, Sanjida, Hatipoglu, Manolya Kukut, Benbrook, Doris M., Garcia-Contreras, Lucila
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342475/
https://ncbi.nlm.nih.gov/pubmed/30196041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.08.024
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