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Pharmacokinetics and interspecies scaling of a novel, orally-bioavailable anti-cancer drug, SHetA2

SHetA2 is a small molecule drug with promising cancer prevention and therapeutic activity and a high preclinical safety profile. The study objectives were to perform interspecies scaling and pharmacokinetic (PK) modeling of SHetA2 for human PK prediction. The PK data obtained from mice, rats, and do...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sharma, Ankur, Benbrook, Doris Mangiaracina, Woo, Sukyung
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892888/
https://ncbi.nlm.nih.gov/pubmed/29634717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194046
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