An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

It is anticipated that bioactive fragments of the extracellular matrix (matrikines) can influence the development and progression of chronic diseases. The enzyme leukotriene A(4) hydrolase (LTA(4)H) mediates opposing proinflammatory and anti-inflammatory activities, through the generation of leukotr...

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發表在:Sci Transl Med
Main Authors: Patel, Dhiren F., Peiró, Teresa, Shoemark, Amelia, Akthar, Samia, Walker, Simone A., Grabiec, Aleksander M., Jackson, Patricia L., Hussell, Tracy, Gaggar, Amit, Xu, Xin, Trevor, Jennifer L., Li, Jindong, Steele, Chad, Tavernier, Gael, Blalock, J. Edwin, Niven, Robert M., Gregory, Lisa G., Simpson, Angela, Lloyd, Clare M., Snelgrove, Robert J.
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342449/
https://ncbi.nlm.nih.gov/pubmed/30135247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaq0693
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