Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations

BACKGROUND: The fungal allergen Alternaria alternata is implicated in severe asthma and rapid onset life-threatening exacerbations of disease. However, the mechanisms that underlie this severe pathogenicity remain unclear. OBJECTIVE: We sought to investigate the mechanism whereby Alternaria was capa...

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Detalhes bibliográficos
Main Authors: Snelgrove, Robert J., Gregory, Lisa G., Peiró, Teresa, Akthar, Samia, Campbell, Gaynor A., Walker, Simone A., Lloyd, Clare M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mosby 2014
Assuntos:
Asthma and Lower Airway Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152000/
https://ncbi.nlm.nih.gov/pubmed/24636086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.02.002
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